作者：庞宇, 何鸿, 蒋伟
作者单位：重庆邮电大学 光电信息感测与传输技术重庆市重点实验室，重庆 400065
关键词：示波法;血压检测;振荡脉搏波;峰值点定位;拉格朗日插值法
摘要：
血压是评估心血管风险等疾病的重要体征参数之一，可穿戴血压检测系统具有体积小、使用方便等优点。针对传统可穿戴血压检测系统算法复杂的问题，通过STM32单片机、压力传感器等器件来采集数据并设计血压检测算法。利用压力表测试出压力和压力传感器输出电压值的定量关系，采用移动平均滤波器对混合血压信号进行分离，形态学滤波去除基线漂移等干扰。提出基于基波信号的方法来完成振荡脉搏波的幅值匹配，并采用拉格朗日插值法进行离散波峰序列的求值查找。结合变幅度系数法来查找序列峰值的特征点，匹配静压力信号来计算血压。经验证，该算法计算的血压值与标准听诊法结果具有较强的数据一致性，符合ANSI/AAMI标准，能够作为血压判定依据。
Research and design of wearable blood pressure detection system algorithm
PANG Yu, HE Hong, JIANG Wei
Chongqing Key Laboratory of Optoelectronic Information Sensing and Transmission Technology, Chongqing University of Posts and Telecommunications, Chongqing 400065, China
Abstract: Blood pressure is one of the most important signs for assessing cardiovascular risk and other diseases. Wearable blood pressure detection system has the advantages of small size and convenience. Because the algorithm of traditional blood pressure detection system is complicated, STM32 microcontroller, pressure sensor and other devices are used to collect data and design blood pressure detection algorithm. With the help of pressure gauge, the quantitative relationship between pressure and the output voltage of the pressure sensor is tested. the mixed blood pressure signals were separated by moving average filter, and the interference such as baseline drift was removed by morphological filter. A method based on fundamental signal is proposed to match the amplitude of oscillatory pulse wave. The Lagrange interpolation method is used to find the discrete wave peak sequence. Variable amplitude coefficient method was used to find the characteristic points of the sequence peak value, and the blood pressure was calculated by matching the static pressure signal. After verification, the blood pressure value calculated after processing the signal has strong data consistency with the result of standard auscultation method. The blood pressure measuring device conforms to ANSI / AAMI standard, it can be used as the basis of blood pressure determination.
Keywords: oscillography;blood pressure detection;oscillating pulse wave;peak location;Lagrange interpolation
2022, 48(6):99-105 收稿日期: 2021-05-07;收到修改稿日期: 2021-06-24
基金项目: 国家自然科学基金（61671091）
作者简介: 庞宇（1978-），男，四川德阳市人，博士，教授，研究方向为通信集成电路设计，无线通信和智慧医疗
参考文献
[1] 徐劲松, 上官青, 苏海. 心房颤动、血压和血压测量[J]. 中华高血压杂志, 2015, 23(2): 122-124
[2] 霍旭阳. 电子血压计可靠性的讨论与展望[J]. 中国医疗设备, 2016, 31(8): 71-74
[3] 郑敏慧, 郑瑞华, 俞坚, 等. 基于示波法腕式电子血压计校准装置的研究[J]. 计量与测试技术, 2018, 45(11): 47-49
[4] 华斌, 陈玉婷, 吕青普. 一种结合传统示波法与新型k-means算法的血压判定方法[J]. 中国生物医学工程学报, 2020, 39(2): 152-159
[5] 温亮, 李振波, 陈佳品, 等. 基于高斯拟合的神经网络血压测量算法[J]. 传感器与微系统, 2014, 33(4): 132-134+138
[6] AHMADREZA A, GEORGE C, HAMILTON L. A novel automated blood pressure estimation algorithm using sequences of Korotkoff sounds[J]. IEEE Journal of Biomedical and Health Informatics, 2020, 25(4): 1257-1264
[7] AISTEJA S, JURATE B, DOVILE P. Auscultatory versus oscillometric blood pressure measurement in patients with atrial fibrillation and arterial hypertension[J]. BMC Cardiovascular Disorders, 2017, 17(1): 1-8
[8] 周号一, 俞永伟, 刘广清, 等. 基于示波法与STM32的电子血压计设计[J]. 传感器与微系统, 2020, 39(2): 85-87
[9] 董金陇, 杨录, 刘康驰, 等. 脉搏信号伪基线去除方法研究[J]. 中国测试, 2021, 47(4): 19-25
[10] 邱忠超, 洪利, 蔡建羡, 等. 基于数学形态学滤波的漏磁信号预处理方法研究[J]. 中国测试, 2020, 46(3): 1-5
[11] 曹玉波, 李健, 周琦祥, 等. 一阶惯性数字化滤波算法研究及应用[J]. 吉林化工学院学报, 2019, 36(11): 50-52
[12] 杨皓翔, 李涛, 张招金, 等. 基于拉格朗日插值法的新陈代谢模型在边坡位移监测中的应用[J]. 安全与环境工程, 2017, 24(2): 33-38
[13] KANAKO S, YUKIKO H, HAKUO T. Validation of two automatic devices, Omron HEM-6232T and HEM-6181, for self-measurement of blood pressure at the wrist according to the ANSI/AAMI/ISO 81060-2: 2013 protocol and the European Society of Hypertension International Protocol revision 2010[J]. Vascular health and risk management, 2019, 15(2): 23-28
