作者：周兆熊1, 袁键键2, 邵华2, 殷万武2, 王成勇3
作者单位：1. 上海交通大学医学院附属仁济医院, 上海 200120;
2. 上海交通大学机械与动力工程学院, 上海 200240;
3. 广东工业大学机电工程学院, 广东 广州 510006
关键词：血管阻塞;机械辅助血管介入治疗;力信号;强度及长度
摘要：
针对血管中阻塞体强度及长度的特征测量复杂、精度低、不能实时获取问题，提出根据导丝在血管中推进力信号的变化判断阻塞体强度及长度的试验方法。搭建导丝位置实时反馈及力信号采集的机械辅助血管介入治疗装置，采用不同浓度的凝胶模拟血管阻塞物，利用力反馈信号，从穿刺力和阻塞体内运动段输送阻力斜率分析阻塞物强度对直头导丝输送的影响。试验结果表明，导丝穿刺力与明胶溶液浓度呈现高度线性相关，阻塞物强度越高对导丝输送运动的阻滞作用越明显，且基于输送阻力刺入、刺出尖峰力信号推算的阻塞体长度与阻塞体实际长度基本一致，相对误差低于5%。实验结果显示该装置应用临床治疗有一定的可行性。
Experimental study on the relationship between the force of guide wire in mechanically assisted vascular intervention and the strength and length of vascular obstruction
ZHOU Zhaoxiong1, YUAN Jianjian2, SHAO Hua2, YIN Wanwu2, WANG Chengyong3
1. Renji Hospital, Medical College of Shanghai Jiao Tong University, Shanghai 200120, China;
2. School of Mechanical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China;
3. School of Electromechanical Engineering, Guangdong University of Technology, Guangzhou 510006, China
Abstract: Aiming at the problem that the characteristics of the intensity and length of the obstructed body in the blood vessel are complex and can not be obtained in real time. A test method is proposed for judging the strength and length of the obstruction body according to the change of the propulsion signal in the blood vessel. A mechanical - assisted vascular interventional device for the real - time feedback and force signal acquisition of the guide wire position was established. Using different concentrations gel to simulate vascular obstruction and feedback force signal, the influence of the strength of the obstruction on the transmission of the straight guide wire was analyzed from the slope of the transmission resistance from movement and the puncture force of obstruction. The results show that The puncture force of the guide wire is highly linearly related to the gelatin solution concentration. The higher the intensity of the obstruction is, the more obvious the blocking effect is on the guide wire transport movement, and the length of the obstruction is estimated to be consistent with the actual length of the obstruction body. The relative error is less than 5%. The current experimental results suggest that the clinical application of the device has certain feasibility.
Keywords: vascular obstruction;mechanically assisted vascular intervention;force signal;strength and length
2019, 45(7):31-36 收稿日期: 2017-07-12;收到修改稿日期: 2017-11-09
基金项目:
作者简介: 周兆熊(1968-),男,上海市人,副教授,博士,主要研究方向为动脉硬化的病理生理学机制、分子影像学诊断和靶向治疗
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