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首页> 《中国测试》期刊 >本期导读>四川典型水域表层水体抗生素残留特征与风险评估

四川典型水域表层水体抗生素残留特征与风险评估

123    2020-10-27

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作者:巫明毫1, 沙菁洲2, 侯永斌2, 刘超兰3, 郭义东3, 张力4, 林家富3

作者单位:1. 成都医学院药学院,四川 成都 610000;
2. 四川省生态环境厅四川省固体废物与化学品管理中心,四川 成都 610000;
3. 成都大学四川抗菌素工业研究所 抗生素研究与再评价四川省重点实验室,四川 成都 610000;
4. 四川省生态环境科学研究院固体废物处理技术研究所 四川省环境保护重金属污染防治重点实验室,四川 成都 610000


关键词:典型湖泊/水库;表层水;抗生素;风险评估


摘要:

为评价四川4个典型湖泊/水库的抗生素残留特征及相关风险等级,采用超高液相色谱-串联质谱仪对水体中15种抗生素的残留水平进行测定,并通过熵值法和蒙特卡洛法对残留抗生素进行风险评估。结果显示:4个水体样本共检出14种抗生素,以兽用抗生为主,其中四环素浓度最高。黑龙滩水库抗生素残留水平较高,且存在高选择性耐药风险,其他3地抗生素残留水平与国内部分湖泊河流相比处于普通水平,且选择性耐药风险水平低;4个水体监测点均存在高环境风险。成人、儿童经饮水途径摄入抗生素的累积健康风险指数在9.5×10–5~4.03×10–3之间,且儿童要高于成人。4个典型水域兽用抗生素残留量与检出率相对较高,且环境风险水平较高。


Characteristics and risk assessment of antibiotic residues in surface water of typical waters in Sichuan
WU Minghao1, SHA Jingzhou2, HOU Yongbin2, LIU Chaolan3, GUO Yidong3, ZHANG Li4, LIN Jiafu3
1. School of Pharmacy, Chengdu Medical College, Chengdu 610000, China;
2. Sichuan Solid Waste and Chemicals Management Center, Department of Ecology and Environment of Sichuan Province, Chengdu 610000, China;
3. Antibiotics Research and Re-evaluation Key Laboratory of Sichuan Province, Sichuan Industrial Institute of Antibiotics (SIIA), Chengdu University, Chengdu 610000, China;
4. Sichuan Environmental Protection Key Laboratory of Pollution Control for Heavy Metals, Department of Solid Waste Treatment Technology, Sichuan Academy of Environmental Sciences, Chengdu 610000, China
Abstract: In order to evaluate the residual characteristics and related risk grades of antibiotics in four typical lakes/reservoirs in Sichuan, ultra-high liquid chromatography-tandem mass spectrometry was used to determine the residual levels of 15 kinds of antibiotics in water. Entropy method and Monte Carlo method were used to evaluate the risk of residual antibiotics. The results showed that a total of 14 antibiotics were detected in 4 water samples, mainly for veterinary antibiotics, among which the concentration of tetracycline was the highest. The residual level of antibiotics in Heilongtan Reservoir is high, and there is a risk of high selective drug resistance, and the residual level of antibiotics in the other three places is at a general level compared with some lakes and rivers in China. and the risk level of selective drug resistance is low;four water monitoring sites all have high environmental risk. The cumulative health risk index of adults and children who ingest antibiotics through drinking water is between 9.5×10–5-4.03×10–3, and that of children is higher than that of adults. The residue and detection rate of veterinary antibiotics in four typical waters are relatively high, and the level of environmental risk is high.
Keywords: typical lakes/reservoirs;surface water;antibiotics;risk assessment
2020, 46(10):78-85  收稿日期: 2020-06-30;收到修改稿日期: 2020-08-02
基金项目: 四川省抗生素生产企业含抗生素废物(渣)现状调查及防治对策研究项目(2018HB27);四川省环境抗生素残留量对环境微生态的影响研究及风险预测项目(2019HB16)
作者简介: 巫明毫(1994-),男,四川西昌市人,硕士研究生,专业方向为微生物与生化药学
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